HMM Summary Page: TIGR03392

Functioncysteine desulfurase, catalytic subunit CsdA
Gene SymbolcsdA
Trusted Cutoff493.60
Domain Trusted Cutoff493.60
Noise Cutoff493.40
Domain Noise Cutoff493.40
Isology Typeequivalog
EC Number2.8.1.7
HMM Length398
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0016226: iron-sulfur cluster assembly biological_process
GO:0031071: cysteine desulfurase activity molecular_function
AuthorHaft DH
Entry DateApr 23 2007 1:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are CsdS. This protein, found Escherichia coli, Yersinia pestis, Photorhabdus luminescens, and related species, and related to SufS, works together with and physically interacts with CsdE (a paralog of SufE). CsdA has cysteine desulfurase activity that is enhanced by CsdE, a sulfur acceptor protein. This gene pair, although involved in FeS cluster biosynthesis, is not found next to other such genes as are its paralogs from the Suf or Isc systems.
ReferencesRN [1] RM PMID: 15901727 RT Analysis of the heteromeric CsdA-CsdE cysteine desulfurase, assisting Fe-S cluster biogenesis in Escherichia coli. RA Loiseau L, Ollagnier-de Choudens S, Lascoux D, Forest E, Fontecave M, Barras F RL J Biol Chem. 2005 Jul 22;280(29):26760-9.
Genome PropertyGenProp0739: iron-sulfur cluster assembly CsdA-CsdE system (HMM)