HMM Summary Page: TIGR03385

FunctionCoA-disulfide reductase
Gene Symbolcdr
Trusted Cutoff578.80
Domain Trusted Cutoff578.80
Noise Cutoff530.80
Domain Noise Cutoff530.80
Isology Typeequivalog
EC Number1.8.1.14
HMM Length439
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0006800: oxygen and reactive oxygen species metabolic process biological_process
GO:0050451: CoA-disulfide reductase activity molecular_function
AuthorHaft DH
Entry DateApr 18 2007 8:39AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are CoA-disulfide reductase (EC, as characterized in Staphylococcus aureus, Pyrococcus horikoshii, and Borrelia burgdorferi, and inferred in several other species on the basis of high levels of CoA and an absence of glutathione as a protective thiol.
ReferencesRN [1] RM PMID: 15720393 RT Discovery and characterization of a Coenzyme A disulfide reductase from Pyrococcus horikoshii. Implications for this disulfide metabolism of anaerobic hyperthermophiles. RA Harris DR, Ward DE, Feasel JM, Lancaster KM, Murphy RD, Mallet TC, Crane EJ 3rd RL FEBS J. 2005 Mar;272(5):1189-200. RN [2] RM PMID: 16981688 RT Structure of coenzyme A-disulfide reductase from Staphylococcus aureus at 1.54 A resolution. RA Mallett TC, Wallen JR, Karplus PA, Sakai H, Tsukihara T, Claiborne A RL Biochemistry. 2006 Sep 26;45(38):11278-89. RN [3] RM PMID: 16390443 RT Borrelia burgdorferi bb0728 encodes a coenzyme A disulphide reductase whose function suggests a role in intracellular redox and the oxidative stress response. RA Boylan JA, Hummel CS, Benoit S, Garcia-Lara J, Treglown-Downey J, Crane EJ 3rd, Gherardini FC RL Mol Microbiol. 2006 Jan;59(2):475-86.