| Accession | TIGR03384 |
| Name | betaine_BetI |
| Function | transcriptional repressor BetI |
| Gene Symbol | betI |
| Trusted Cutoff | 201.30 |
| Domain Trusted Cutoff | 201.30 |
| Noise Cutoff | 127.70 |
| Domain Noise Cutoff | 127.70 |
| Isology Type | equivalog |
| HMM Length | 189 |
| Mainrole Category | Regulatory functions |
| Subrole Category | DNA interactions |
| Gene Ontology Term | GO:0016566: specific transcriptional repressor activity molecular_function |
| | GO:0019285: glycine betaine biosynthetic process from choline biological_process |
| | GO:0045892: negative regulation of transcription, DNA-dependent biological_process |
| Author | Haft DH |
| Entry Date | Apr 17 2007 2:23PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | BetI is a DNA-binding transcriptional repressor of the bet (betaine) regulon. In sequence, it is related to TetR (PF00440). Choline, through BetI, induces the expression of the betaine biosynthesis genes betA and betB by derepression. The choline porter gene betT is also part of this regulon in Escherichia coli. Note that a different transcriptional regulator, ArcA, controls the expression of bet regulon genes in response to oxygen, as BetA is an oxygen-dependent enzyme. |
| References | RN [1]
RM PMID: 9141699
RT Molecular characterization of the bet genes encoding glycine betaine synthesis in Sinorhizobium meliloti 102F34.
RA Pocard JA, Vincent N, Boncompagni E, Smith LT, Poggi MC, Le Rudulier D
RL Microbiology. 1997 Apr;143 ( Pt 4):1369-79. |
| Genome Property | GenProp0147: glycine betaine biosynthesis from choline (HMM) |
