| Accession | TIGR03367 |
| Name | queuosine_QueD |
| Function | queuosine biosynthesis protein QueD |
| Gene Symbol | queD |
| Trusted Cutoff | 89.25 |
| Domain Trusted Cutoff | 89.25 |
| Noise Cutoff | 76.90 |
| Domain Noise Cutoff | 76.90 |
| Isology Type | equivalog |
| HMM Length | 92 |
| Mainrole Category | Protein synthesis |
| Subrole Category | tRNA and rRNA base modification |
| Gene Ontology Term | GO:0003824: catalytic activity molecular_function |
| | GO:0008616: queuosine biosynthetic process biological_process |
| Author | Haft DH |
| Entry Date | Mar 22 2007 2:51PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein family, closely related to eukaryotic 6-pyruvoyl tetrahydrobiopterin synthase enzymes, are the QueD protein of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of tRNAs for Tyr, His, Asp, and Asn in many species. This modification, although widespread, appears not to be important for viability. The queuosine precursor made by this enzyme may be converted instead to archeaosine as in some Archaea. |
| References | RN [1]
RM PMID: 14660578
RT Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine.
RA Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V
RL J Biol Chem. 2004 Feb 20;279(8):6280-5. |
