HMM Summary Page: TIGR03367

Functionqueuosine biosynthesis protein QueD
Gene SymbolqueD
Trusted Cutoff89.25
Domain Trusted Cutoff89.25
Noise Cutoff76.90
Domain Noise Cutoff76.90
Isology Typeequivalog
HMM Length92
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0003824: catalytic activity molecular_function
GO:0008616: queuosine biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 22 2007 2:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family, closely related to eukaryotic 6-pyruvoyl tetrahydrobiopterin synthase enzymes, are the QueD protein of queuosine biosynthesis. Queuosine is a hypermodified base in the wobble position of tRNAs for Tyr, His, Asp, and Asn in many species. This modification, although widespread, appears not to be important for viability. The queuosine precursor made by this enzyme may be converted instead to archeaosine as in some Archaea.
ReferencesRN [1] RM PMID: 14660578 RT Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. RA Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V RL J Biol Chem. 2004 Feb 20;279(8):6280-5.