HMM Summary Page: TIGR03365

Function7-cyano-7-deazaguanosine (preQ0) biosynthesis protein QueE
Gene SymbolqueE
Trusted Cutoff206.10
Domain Trusted Cutoff206.10
Noise Cutoff99.25
Domain Noise Cutoff99.25
Isology Typeequivalog
HMM Length238
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
AuthorHaft DH
Entry DateMar 20 2007 3:54PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis uncharacterized enzyme, designated QueE, participates in the biosynthesis, from GTP, of 7-cyano-7-deazaguanosine, also called preQ0 because in many species it is a precursor of queuosine. In most Archaea, it is instead the precursor of a different tRNA modified base, archaeosine.
ReferencesRN [1] RM PMID: 14660578 RT Identification of four genes necessary for biosynthesis of the modified nucleoside queuosine. RA Reader JS, Metzgar D, Schimmel P, de Crecy-Lagard V RL J Biol Chem. 2004 Feb 20;279(8):6280-5.