HMM Summary Page: TIGR03349

Functiontype IV/VI secretion system protein, DotU family
Trusted Cutoff89.95
Domain Trusted Cutoff89.95
Noise Cutoff51.40
Domain Noise Cutoff51.40
Isology Typesubfamily_domain
HMM Length211
Mainrole CategoryProtein fate
Subrole CategoryProtein and peptide secretion and trafficking
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0052048: interaction with host via secreted substance involved in symbiotic interaction biological_process
AuthorHaft DH
Entry DateMar 15 2007 9:31AM
Last ModifiedAug 24 2011 4:15PM
CommentAt least two families of proteins, often encoded by adjacent genes, show sequence similarity due to homology between type IV secretion systems and type VI secretion systems. One is the IcmF family (TIGR03348). The other is the family described by this model. Members include DotU from the Legionella pneumophila type IV secretion system. Many of the members of this protein family from type VI secretion systems have an additional C-terminal domain with OmpA/MotB homology.
ReferencesRN [1] RM PMID: 16763151 RT A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. RA Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ RL Science. 2006 Jun 9;312(5779):1526-30.
Genome PropertyGenProp0735: type VI secretion (HMM)