HMM Summary Page: TIGR03346

FunctionATP-dependent chaperone protein ClpB
Gene SymbolclpB
Trusted Cutoff1232.10
Domain Trusted Cutoff1232.10
Noise Cutoff1085.10
Domain Noise Cutoff1085.10
Isology Typeequivalog
HMM Length853
Mainrole CategoryProtein fate
Subrole CategoryProtein folding and stabilization
Gene Ontology TermGO:0006457: protein folding biological_process
GO:0042623: ATPase activity, coupled molecular_function
AuthorHaft DH
Entry DateMar 14 2007 2:29PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the bacterial ATP-dependent chaperone ClpB. This protein belongs to the AAA family, ATPases associated with various cellular activities (PF00004). This molecular chaperone does not act as a protease, but rather serves to disaggregate misfolded and aggregated proteins.
ReferencesRN [1] RM PMID: 15037241 RT The ClpB/Hsp104 molecular chaperone-a protein disaggregating machine. RA Lee S, Sowa ME, Choi JM, Tsai FT RL J Struct Biol. 2004 Apr-May;146(1-2):99-105.