HMM Summary Page: TIGR03344

Functiontype VI secretion system effector, Hcp1 family
Trusted Cutoff58.90
Domain Trusted Cutoff58.90
Noise Cutoff32.40
Domain Noise Cutoff32.40
Isology Typesubfamily
HMM Length167
Mainrole CategoryCellular processes
Subrole CategoryPathogenesis
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0009405: pathogenesis biological_process
GO:0052048: interaction with host via secreted substance involved in symbiotic interaction biological_process
AuthorHaft DH
Entry DateMar 14 2007 10:09AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family includes Hcp1 (hemolysin coregulated protein 1), an exported, homohexameric ring-forming virulence protein from Pseudomonas aeruginosa. Hcp1 lacks a conventional signal sequence and is instead exported by means of the type VI secretion system, encoded by a pathogenicity cluster of a class previously designated IAHP (IcmF-associated homologous protein). Homologs of Hcp1, in this protein family, are found in various bacteria of which most but not all are known pathogens. Pathogens may have many multiple members of this family, with three to ten in Erwinia carotovora, Yersinia pestis, uropathogenic Escherichia coli, and the insect pathogen Photorhabdus luminescens.
ReferencesRN [1] RM PMID: 16763151 RT A virulence locus of Pseudomonas aeruginosa encodes a protein secretion apparatus. RA Mougous JD, Cuff ME, Raunser S, Shen A, Zhou M, Gifford CA, Goodman AL, Joachimiak G, Ordonez CL, Lory S, Walz T, Joachimiak A, Mekalanos JJ RL Science. 2006 Jun 9;312(5779):1526-30.
Genome PropertyGenProp0735: type VI secretion (HMM)