HMM Summary Page: TIGR03341

FunctionIscR-regulated protein YhgI
Gene SymbolyhgI
Trusted Cutoff269.35
Domain Trusted Cutoff269.35
Noise Cutoff97.85
Domain Noise Cutoff97.85
Isology Typehypoth_equivalog
HMM Length190
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0016226: iron-sulfur cluster assembly biological_process
AuthorHaft DH
Entry DateMar 12 2007 4:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentIscR (TIGR02010) is an iron-sulfur cluster-binding transcriptional regulator (see Genome Property GenProp0138). Members of this protein family include YhgI, whose expression is under control of IscR, and show sequence similarity to IscA, a known protein of iron-sulfur cluster biosynthesis. These two lines of evidence strongly suggest a role as an iron-sulfur cluster biosynthesis protein. An older study designated this protein GntY and suggested a role for it and for the product of an adjacent gene, based on complementation studies, in gluconate utilization.
ReferencesDR PF01521; Fe-S_biosyn; HesB-like domain RN [1] RM PMID: 16677314 RT IscR-dependent gene expression links iron-sulphur cluster assembly to the control of O2-regulated genes in Escherichia coli. RA Giel JL, Rodionov D, Liu M, Blattner FR, Kiley PJ RL Mol Microbiol. 2006 May;60(4):1058-75. RN [2] RM PMID: 9871335 RT The gluconate high affinity transport of GntI in Escherichia coli involves a multicomponent complex system. RA Porco A, Alonso G, Isturiz T RL J Basic Microbiol. 1998;38(5-6):395-404.