HMM Summary Page: TIGR03336

Functionindolepyruvate ferredoxin oxidoreductase, alpha subunit
Gene SymboliorA
Trusted Cutoff650.90
Domain Trusted Cutoff650.90
Noise Cutoff343.55
Domain Noise Cutoff343.55
Isology Typeequivalog
EC Number1.2.7.8
HMM Length595
AuthorHaft DH
Entry DateMar 7 2007 1:52PM
Last ModifiedFeb 14 2011 3:27PM
CommentIndolepyruvate ferredoxin oxidoreductase (IOR) is an alpha 2/beta 2 tetramer related to ketoacid oxidoreductases for pyruvate (, POR), 2-ketoglutarate (, KOR), and 2-oxoisovalerate (, VOR). These multi-subunit enzymes typically are found in anaerobes and are inactiviated by oxygen. IOR in Pyrococcus acts in fermentation of all three aromatic amino acids, following removal of the amino group by transamination. In Methanococcus maripaludis, by contrast, IOR acts in the opposite direction, in pathways of amino acid biosynthesis from phenylacetate, indoleacetate, and p-hydroxyphenylacetate. In M. maripaludis and many other species, iorA and iorB are found next to an apparent phenylacetate-CoA ligase.
ReferencesRN [1] RM PMID: 15262931 RT Two biosynthetic pathways for aromatic amino acids in the archaeon Methanococcus maripaludis. RA Porat I, Waters BW, Teng Q, Whitman WB RL J Bacteriol. 2004 Aug;186(15):4940-50.