HMM Summary Page: TIGR03335

Functioncoenzyme F390 synthetase
Gene SymbolftsA
Trusted Cutoff458.70
Domain Trusted Cutoff458.70
Noise Cutoff458.45
Domain Noise Cutoff458.45
Isology Typeequivalog
EC Number2.7.7.-
HMM Length445
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
AuthorHaft DH
Entry DateMar 7 2007 1:21PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme, characterized in Methanobacterium thermoautotrophicum and found in several other methanogens, modifies coenzyme F420 by ligation of AMP (or GMP) from ATP (or GTP). On F420, it activates an aromatic hydroxyl group, which is unusual chemistry for an adenylyltransferase. This enzyme name has been attached to numbers of uncharacterized genes likely to instead act as phenylacetate CoA ligase, based on proximity to predicted indolepyruvate ferredoxin oxidoreductase ( genes. The enzyme acts during transient exposure of the organism to oxygen.
ReferencesRN [1] RM PMID: 8550473 RT Coenzyme F390 synthetase from Methanobacterium thermoautotrophicum Marburg belongs to the superfamily of adenylate-forming enzymes. RA Vermeij P, van der Steen RJ, Keltjens JT, Vogels GD, Leisinger T RL J Bacteriol. 1996 Jan;178(2):505-10.