HMM Summary Page: TIGR03330

FunctionS-adenosylmethionine decarboxylase proenzyme
Gene SymbolspeD
Trusted Cutoff75.65
Domain Trusted Cutoff75.65
Noise Cutoff70.45
Domain Noise Cutoff70.45
Isology Typeequivalog
EC Number4.1.1.50
HMM Length112
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryPolyamine biosynthesis
Gene Ontology TermGO:0004014: adenosylmethionine decarboxylase activity molecular_function
GO:0008295: spermidine biosynthetic process biological_process
AuthorHaft DH
Entry DateMar 2 2007 4:51PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the single chain precursor of the two chains of the mature S-adenosylmethionine decarboxylase as found in Methanocaldococcus jannaschii, Bacillus subtilis, and a wide range of other species. It differs substantially in architecture from the form as found in Escherichia coli, and lacks any extended homology to the eukaryotic form (TIGR00535).
ReferencesRN [1] RM PMID: 11073910 RT S-Adenosylmethionine decarboxylase from the archaeon Methanococcus jannaschii: identification of a novel family of pyruvoyl enzymes. RA Kim AD, Graham DE, Seeholzer SH, Markham GD RL J Bacteriol. 2000 Dec;182(23):6667-72.