HMM Summary Page: TIGR03325

Functioncis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase
Gene SymbolbphB
Trusted Cutoff459.85
Domain Trusted Cutoff459.85
Noise Cutoff417.05
Domain Noise Cutoff417.05
Isology Typeequivalog
EC Number1.3.1.56
HMM Length263
AuthorHaft DH
Entry DateFeb 28 2007 1:50PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family occur as the BphD protein of biphenyl catabolism and as the TodD protein of toluene catabolism. Members catalyze the second step in each pathway and proved interchangeable when tested; the first and fourth enzymes in each pathway confer metabolic specificity. In the context of biphenyl degradation, the enzyme acts as cis-2,3-dihydrobiphenyl-2,3-diol dehydrogenase (EC, while in toluene degradation it acts as cis-toluene dihydrodiol dehydrogenase.
ReferencesRN [1] RM PMID: 8349562 RT Gene components responsible for discrete substrate specificity in the metabolism of biphenyl (bph operon) and toluene (tod operon). RA Furukawa K, Hirose J, Suyama A, Zaiki T, Hayashida S RL J Bacteriol. 1993 Aug;175(16):5224-32.