| Accession | TIGR03311 |
| Name | Se_dep_XDH |
| Function | selenium-dependent xanthine dehydrogenase |
| Gene Symbol | xdh |
| Trusted Cutoff | 830.45 |
| Domain Trusted Cutoff | 830.45 |
| Noise Cutoff | 680.95 |
| Domain Noise Cutoff | 680.95 |
| Isology Type | equivalog |
| EC Number | 1.17.1.4 |
| HMM Length | 848 |
| Author | Haft DH |
| Entry Date | Feb 14 2007 3:59PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Members of this protein resemble conventional xanthine dehydrogenase enzymes, which depend on molybdenum cofactor - molybdopterin bound to molybdate with two sulfur atoms as ligands. But all members of this family occur in species that contain markers for the biosynthesis of enzymes with a selenium-containing form of molybdenum cofactor. The member of this family from Enterococcus faecalis has been shown to act as a xanthine dehydrogenenase, and its activity if dependent on SelD (selenophosphate synthase), selenium, and molybdenum. |
| References | RN [1]
RM PMID:21257770
RT A selenium-dependent xanthine dehydrogenase triggers biofilm proliferation in Enterococcus faecalis through oxidant production.
RA Srivastava M, Mallard C, Barke T, Hancock LE, Self WT
RL J Bacteriol. 2011 Apr;193(7):1643-52. doi: 10.1128/JB.01063-10.
RN [2]
RM PMID:18289380
RT Orphan SelD proteins and selenium-dependent molybdenum hydroxylases.
RA Haft DH, Self WT
RL Biol Direct. 2008 Feb 20;3:4. doi: 10.1186/1745-6150-3-4. |
| Genome Property | GenProp0726: selenium-dependent molybdenum hydroxylase system (HMM) |
