HMM Summary Page: TIGR03301
| Accession | TIGR03301 |
| Name | PhnW-AepZ |
| Function | 2-aminoethylphosphonate aminotransferase |
| Trusted Cutoff | 360.80 |
| Domain Trusted Cutoff | 360.80 |
| Noise Cutoff | 290.05 |
| Domain Noise Cutoff | 290.05 |
| Isology Type | subfamily |
| EC Number | 2.6.1.- |
| HMM Length | 355 |
| Author | Selengut J |
| Entry Date | Feb 1 2007 1:38PM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | This family includes a number of 2-aminoethylphosphonate aminotransferases, some of which are indicated to operate in the catabolism of 2-aminoethylphosphonate (AEP) and others which are involved in the biosynthesis of the same compound. The catabolic enzyme (PhnW, [1]) is known to use pyruvate:alanine as the transfer partner and is modeled by the equivalog-level HMM (TIGR02326). The PhnW family is apparently a branch of a larger tree including genes (AepZ) adjacent to others responsible for the biosynthesis of phosphonoacetaldehyde [2]. The identity of the transfer partner is unknown for these enzymes and considering the reversed flux compared to PhnW, it may very well be different. |
| References | RN [1] RM PMID: 12107130 RT The 2-aminoethylphosphonate-specific transaminase of the 2-aminoethylphosphonate degradation pathway. RA Kim AD, Baker AS, Dunaway-Mariano D, Metcalf WW, Wanner BL, Martin BM RL J Bacteriol. 2002 Aug;184(15):4134-40. RN [2] RM PMID: 11035722 RT Bacteroides fragilis NCTC9343 produces at least three distinct capsular polysaccharides: cloning, characterization, and reassignment of polysaccharide B and C biosynthesis loci. RA Coyne MJ, Kalka-Moll W, Tzianabos AO, Kasper DL, Comstock LE RL Infect Immun. 2000 Nov;68(11):6176-81. |
| Genome Property | GenProp0724: phosphonoacetaldehyde biosynthesis from phosphoenolpyruvate (SUBFAMILY) |