HMM Summary Page: TIGR03298

Functiontranscriptional regulator, ArgP family
Gene SymbolargP
Trusted Cutoff273.55
Domain Trusted Cutoff273.55
Noise Cutoff127.45
Domain Noise Cutoff127.45
Isology Typesubfamily
HMM Length292
Mainrole CategoryCellular processes
Subrole CategoryToxin production and resistance
Gene Ontology TermGO:0003677: DNA binding molecular_function
GO:0005737: cytoplasm cellular_component
GO:0006350: transcription biological_process
GO:0008156: negative regulation of DNA replication biological_process
GO:0016564: transcription repressor activity molecular_function
GO:0043200: response to amino acid stimulus biological_process
AuthorHaft DH
Entry DateJan 31 2007 2:25PM
Last ModifiedFeb 14 2011 3:27PM
CommentArgP used to be known as IciA. ArgP is a positive regulator of argK. It is a negative autoregulator in presence of arginine. It competes with DnaA for oriC iteron (13-mer) binding. It activates dnaA and nrd transcription. It has been demonstrated to be part of the pho regulon (PMID:10589831). ArgP mutants convey canavanine (an L-arginine structural homolog) sensitivity (PMID: 15150242).