HMM Summary Page: TIGR03260

Functionmethyl-coenzyme M reductase operon protein D
Gene SymbolmcrD
Trusted Cutoff100.00
Domain Trusted Cutoff100.00
Noise Cutoff50.00
Domain Noise Cutoff50.00
Isology Typeequivalog
HMM Length150
Mainrole CategoryEnergy metabolism
Subrole CategoryMethanogenesis
AuthorHaft DH
Entry DateJan 16 2007 10:06AM
Last ModifiedMay 17 2011 3:15PM
CommentMembers of this protein family are protein D, a non-structural protein, of the operon for methyl coenzyme M reductase, also called coenzyme-B sulfoethylthiotransferase (EC That enzyme, with alpha, beta, and gamma subunits, catalyzes the last step in methanogenesis; it has several modified sites, so accessory proteins are expected. Several methanogens have encode two such enzymes, designated I and II; this model does not separate the isozymes. Proteins in this family are expressed at much lower levels than the methyl-coenzyme M reductase itself and associate and have been shown to form at least transient associations. The precise function is unknown.
ReferencesRN [1] RM PMID: 8268197 RT Association of the mcrD gene product with methyl coenzyme M reductase in Methanococcus vannielii. RA Stroup D, Reeve JN RL Biochim Biophys Acta. 1993 Dec 8;1203(2):175-83.
Genome PropertyGenProp0719: methyl-coenzyme M reductase (HMM)
GenProp0722: methanogenesis marker set (HMM)