HMM Summary Page: TIGR03249

Function5-dehydro-4-deoxyglucarate dehydratase
Gene SymbolkdgD
Trusted Cutoff373.95
Domain Trusted Cutoff373.95
Noise Cutoff332.85
Domain Noise Cutoff332.85
Isology Typeequivalog
EC Number4.2.1.41
HMM Length299
AuthorSelengut J
Entry DateJan 10 2007 1:17PM
Last ModifiedFeb 14 2011 3:27PM
Comment5-dehydro-4-deoxyglucarate dehydratase not only catalyzes the dehydration of the substrate (diol to ketone + water), but causes the decarboxylation of the intermediate product to yield 2-oxoglutarate semialdehyde (2,5-dioxopentanoate). The gene for the enzyme is usually observed in the vicinity of transporters and dehydratases handling D-galactarate and D-gluconate as well as aldehyde dehydrogenases which convert the product to alpha-ketoglutarate.
Genome PropertyGenProp0715: galactarate utilization via 2-oxoglutarate semialdehyde (HMM)
GenProp0717: glucarate utilization via 2-oxoglutarate semialdehyde (HMM)