| Accession | TIGR03247 |
| Name | glucar-dehydr |
| Function | glucarate dehydratase |
| Gene Symbol | gudD |
| Trusted Cutoff | 828.70 |
| Domain Trusted Cutoff | 828.70 |
| Noise Cutoff | 626.05 |
| Domain Noise Cutoff | 626.05 |
| Isology Type | equivalog |
| EC Number | 4.2.1.40 |
| HMM Length | 441 |
| Author | Selengut J |
| Entry Date | Jan 9 2007 9:52AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Glucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase ([1], GenProp0716). The E. coli enzyme has been well-characterized [2]. |
| References | RN [1]
RM PMID: 9772162
RT Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli.
RA Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA
RL Biochemistry. 1998 Oct 13;37(41):14369-75.
RN [2]
RM PMID: 11513584
RT Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli.
RA Gulick AM, Hubbard BK, Gerlt JA, Rayment I
RL Biochemistry. 2001 Aug 28;40(34):10054-62. |
| Genome Property | GenProp0716: glucarate utilization via tartronate semi-aldehyde (HMM) |
| | GenProp0717: glucarate utilization via 2-oxoglutarate semialdehyde (HMM) |
