HMM Summary Page: TIGR03247

Functionglucarate dehydratase
Gene SymbolgudD
Trusted Cutoff828.70
Domain Trusted Cutoff828.70
Noise Cutoff626.05
Domain Noise Cutoff626.05
Isology Typeequivalog
EC Number4.2.1.40
HMM Length441
AuthorSelengut J
Entry DateJan 9 2007 9:52AM
Last ModifiedFeb 14 2011 3:27PM
CommentGlucarate dehydratase converts D-glucarate (and L-idarate, a stereoisomer) to 5-dehydro-4-deoxyglucarate which is subsequently acted on by GarL, tartronate semialdehyde reductase and glycerate kinase ([1], GenProp0716). The E. coli enzyme has been well-characterized [2].
ReferencesRN [1] RM PMID: 9772162 RT Evolution of enzymatic activities in the enolase superfamily: characterization of the (D)-glucarate/galactarate catabolic pathway in Escherichia coli. RA Hubbard BK, Koch M, Palmer DR, Babbitt PC, Gerlt JA RL Biochemistry. 1998 Oct 13;37(41):14369-75. RN [2] RM PMID: 11513584 RT Evolution of enzymatic activities in the enolase superfamily: identification of the general acid catalyst in the active site of D-glucarate dehydratase from Escherichia coli. RA Gulick AM, Hubbard BK, Gerlt JA, Rayment I RL Biochemistry. 2001 Aug 28;40(34):10054-62.
Genome PropertyGenProp0716: glucarate utilization via tartronate semi-aldehyde (HMM)
GenProp0717: glucarate utilization via 2-oxoglutarate semialdehyde (HMM)