HMM Summary Page: TIGR03231

Functionanthranilate 1,2-dioxygenase, small subunit
Gene SymbolantB
Trusted Cutoff213.50
Domain Trusted Cutoff213.50
Noise Cutoff176.20
Domain Noise Cutoff176.20
Isology Typeequivalog
EC Number1.14.12.1
HMM Length155
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006569: tryptophan catabolic process biological_process
GO:0018618: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity molecular_function
AuthorHaft DH
Entry DateJan 2 2007 1:59PM
Last ModifiedFeb 14 2011 3:27PM
CommentAnthranilate (2-aminobenzoate) is an intermediate of tryptophan (Trp) biosynthesis and degradation. Members of this family are the small subunit of anthranilate 1,2-dioxygenase, which acts in Trp degradation by converting anthranilate to catechol. Closely related paralogs typically are the benzoate 1,2-dioxygenase small subunit, among the larger set of ring-hydroxylating dioxygenases.
ReferencesRN [1] RM PMID: 11114907 RT Characterization and evolution of anthranilate 1,2-dioxygenase from Acinetobacter sp. strain ADP1. RA Eby DM, Beharry ZM, Coulter ED, Kurtz DM Jr, Neidle EL RL J Bacteriol. 2001 Jan;183(1):109-18.