HMM Summary Page: TIGR03228

Functionanthranilate 1,2-dioxygenase, large subunit
Gene SymbolantA
Trusted Cutoff671.90
Domain Trusted Cutoff671.90
Noise Cutoff671.65
Domain Noise Cutoff671.65
Isology Typeequivalog
EC Number1.14.12.1
HMM Length438
Mainrole CategoryEnergy metabolism
Subrole CategoryAmino acids and amines
Gene Ontology TermGO:0006569: tryptophan catabolic process biological_process
GO:0018618: anthranilate 1,2-dioxygenase (deaminating, decarboxylating) activity molecular_function
AuthorHaft DH
Entry DateDec 27 2006 10:58AM
Last ModifiedFeb 14 2011 3:27PM
CommentAnthranilate (2-aminobenzoate) is an intermediate of tryptophan (Trp) biosynthesis and degradation. Members of this family are the large subunit of anthranilate 1,2-dioxygenase, which acts in Trp degradation by converting anthranilate to catechol. Closely related paralogs typically are the benzoate 1,2-dioxygenase large subunit, among the larger set of ring-hydroxylating dioxygenases.
ReferencesRN [1] RM PMID: 11114907 RT Characterization and evolution of anthranilate 1,2-dioxygenase from Acinetobacter sp. strain ADP1. RA Eby DM, Beharry ZM, Coulter ED, Kurtz DM Jr, Neidle EL RL J Bacteriol. 2001 Jan;183(1):109-18.