HMM Summary Page: TIGR03217

Function4-hydroxy-2-oxovalerate aldolase
Gene SymboldmpG
Trusted Cutoff286.00
Domain Trusted Cutoff286.00
Noise Cutoff147.55
Domain Noise Cutoff147.55
Isology Typeequivalog
EC Number4.1.3.39
HMM Length334
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0008701: 4-hydroxy-2-oxovalerate aldolase activity molecular_function
AuthorHaft DH
Entry DateDec 19 2006 9:00AM
Last ModifiedDec 12 2011 10:29PM
CommentMembers of this protein family are 4-hydroxy-2-oxovalerate aldolase, also called 4-hydroxy-2-ketovalerate aldolase and 2-oxo-4-hydroxypentanoate aldolase. This enzyme, part of the pathway for the meta-cleavage of catechol, produces pyruvate and acetaldehyde. Acetaldehyde is then converted by acetaldehyde dehydrogenase (acylating) (DmpF; EC to acetyl-CoA. The two enzymes are tightly associated.
ReferencesRN [1] RM PMID: 7496535 RT The 4-hydroxy-2-oxovalerate aldolase and acetaldehyde dehydrogenase (acylating) encoded by the nahM and nahO genes of the naphthalene catabolic plasmid pWW60-22 provide further evidence of conservation of meta-cleavage pathway gene sequences. RA Platt A, Shingler V, Taylor SC, Williams PA RL Microbiology. 1995 Sep;141 ( Pt 9):2223-33. RN [2] RM PMID: 12764229 RT Crystal structure of a bifunctional aldolase-dehydrogenase: sequestering a reactive and volatile intermediate. RA Manjasetty BA, Powlowski J, Vrielink A RL Proc Natl Acad Sci U S A. 2003 Jun 10;100(12):6992-7. Epub 2003 May 22.
Genome PropertyGenProp0708: catechol meta-cleavage pathway (HMM)