HMM Summary Page: TIGR03201

Function6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase
Gene Symbolhad
Trusted Cutoff338.65
Domain Trusted Cutoff338.65
Noise Cutoff213.50
Domain Noise Cutoff213.50
Isology Typeequivalog
EC Number1.1.1.-
HMM Length349
Gene Ontology TermGO:0016491: oxidoreductase activity molecular_function
GO:0019439: aromatic compound catabolic process biological_process
AuthorHaft DH
Entry DateDec 12 2006 1:11PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are 6-hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase, an enzyme in the anaerobic metabolism of aromatic enzymes by way of benzoyl-CoA, as seen in Thauera aromatica, Geobacter metallireducens, and Azoarcus sp. The experimentally characterized form from T. aromatica uses only NAD+, not NADP+. Note that Rhodopseudomonas palustris uses a different pathway to perform a similar degradation of benzoyl-CoA to 3-hydroxpimelyl-CoA.
ReferencesRN [1] RM PMID: 10406950 RT 6-Hydroxycyclohex-1-ene-1-carbonyl-CoA dehydrogenase and 6-oxocyclohex-1-ene-1-carbonyl-CoA hydrolase, enzymes of the benzoyl-CoA pathway of anaerobic aromatic metabolism in the denitrifying bacterium Thauera aromatica. RA Laempe D, Jahn M, Fuchs G RL Eur J Biochem. 1999 Jul;263(2):420-9.
Genome PropertyGenProp0706: cyclohexa-1,5-diene-1-carbonyl-CoA to 3-hydroxypimelyl-CoA, dch/had/oah pathway (HMM)