HMM Summary Page: TIGR03187

FunctionDGQHR domain
Trusted Cutoff58.85
Domain Trusted Cutoff58.85
Noise Cutoff51.45
Domain Noise Cutoff51.45
Isology Typedomain
HMM Length276
AuthorHaft DH
Entry DateDec 5 2006 9:12AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis highly divergent, uncharacterized domain has several absolutely conserved residues, including a QR pair and FxxxN motif. Its most striking feature, however, is a near invariant pentapeptide motif DGQHR. Several different subfamilies occur specifically as a part of DNA phosphorothioation systems, previously called DND (DNA instability during electrophoresis), while others (e.g. CPS_2936) occur in other contexts suggestive of lateral gene transfer (sporadic distribution of helicase-containing cassettes). The region described by this model is about 280 amino acids in length; additional sequences show local sequence similarity.