HMM Summary Page: TIGR03186

Functionalpha-ketoglutarate dehydrogenase
Gene SymbolmdeB
Trusted Cutoff1408.30
Domain Trusted Cutoff1408.30
Noise Cutoff1356.40
Domain Noise Cutoff1356.40
Isology Typeexception
HMM Length889
AuthorHaft DH
Entry DateDec 4 2006 4:42PM
Last ModifiedFeb 14 2011 3:27PM
CommentSeveral bacterial species have a paralog to homodimeric form of the pyruvate dehydrogenase E1 component (see model TIGR00759), often encoded next to L-methionine gamma-lyase gene (mdeA). The member from a strain of Pseudomonas putida was shown to act on alpha-ketobutyrate, which is produced by MdeA.This model serves as an exception model to TIGR00759, as other proteins hitting TIGR00759 should be identified as the pyruvate dehydrogenase E1 component.
ReferencesRN [1] RM PMID: 9190812 RT Molecular characterization of the mde operon involved in L-methionine catabolism of Pseudomonas putida. RA Inoue H, Inagaki K, Eriguchi SI, Tamura T, Esaki N, Soda K, Tanaka H RL J Bacteriol. 1997 Jun;179(12):3956-62.