HMM Summary Page: TIGR03180

FunctionOHCU decarboxylase
Gene SymboluraD
Trusted Cutoff139.40
Domain Trusted Cutoff139.40
Noise Cutoff85.10
Domain Noise Cutoff85.10
Isology Typeequivalog_domain
EC Number4.1.1.-
HMM Length158
Gene Ontology TermGO:0019628: urate catabolic process biological_process
AuthorSelengut J
Entry DateNov 30 2006 11:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentPreviously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus [1]. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model. This model is a separate (but related) clade from that represented by TIGR3164. This model places a second homolog in streptomyces species which (are not in the vicinity of other urate catabolism associated genes) below the trusted cutoff.
ReferencesRN [1] RM PMID: 16462750 RT Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes. RA Ramazzina I, Folli C, Secchi A, Berni R, Percudani R RL Nat Chem Biol. 2006 Mar;2(3):144-8. Epub 2006 Feb 5.
Genome PropertyGenProp0688: urate catabolism to allantoin (HMM)