| Accession | TIGR03180 |
| Name | UraD_2 |
| Function | OHCU decarboxylase |
| Gene Symbol | uraD |
| Trusted Cutoff | 139.40 |
| Domain Trusted Cutoff | 139.40 |
| Noise Cutoff | 85.10 |
| Domain Noise Cutoff | 85.10 |
| Isology Type | equivalog_domain |
| EC Number | 4.1.1.- |
| HMM Length | 158 |
| Gene Ontology Term | GO:0019628: urate catabolic process biological_process |
| Author | Selengut J |
| Entry Date | Nov 30 2006 11:13AM |
| Last Modified | Feb 14 2011 3:27PM |
| Comment | Previously thought to only proceed spontaneously, the decarboxylation of 2-oxo-4-hydroxy-4-carboxy--5-ureidoimidazoline (OHCU) has been recently been shown to be catalyzed by this enzyme in Mus musculus [1]. Homologs of this enzyme are found adjacent to and fused with uricase in a number of prokaryotes and are represented by this model. This model is a separate (but related) clade from that represented by TIGR3164. This model places a second homolog in streptomyces species which (are not in the vicinity of other urate catabolism associated genes) below the trusted cutoff. |
| References | RN [1]
RM PMID: 16462750
RT Completing the uric acid degradation pathway through phylogenetic comparison of whole genomes.
RA Ramazzina I, Folli C, Secchi A, Berni R, Percudani R
RL Nat Chem Biol. 2006 Mar;2(3):144-8. Epub 2006 Feb 5. |
| Genome Property | GenProp0688: urate catabolism to allantoin (HMM) |
