HMM Summary Page: TIGR03176

Functionallantoate amidohydrolase
Gene SymbolallC
Trusted Cutoff597.75
Domain Trusted Cutoff597.75
Noise Cutoff535.15
Domain Noise Cutoff535.15
Isology Typeequivalog
EC Number3.5.3.9
HMM Length406
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryNitrogen metabolism
Gene Ontology TermGO:0009442: allantoin assimilation pathway biological_process
GO:0047652: allantoate deiminase activity molecular_function
AuthorSelengut J
Entry DateNov 29 2006 3:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the breakdown of allantoate [1], first to ureidoglycine by hydrolysis and then decarboxylation of one of the two equivalent ureido groups. Ureidoglycine then spontaneously exchanges ammonia for water resulting in ureidoglycolate. This enzyme is an alternative to allantoicase ( which releases urea.
ReferencesRN [1] RM PMID: 10601204 RT Genetic analysis of a chromosomal region containing genes required for assimilation of allantoin nitrogen and linked glyoxylate metabolism in Escherichia coli. RA Cusa E, Obradors N, Baldoma L, Badia J, Aguilar J RL J Bacteriol. 1999 Dec;181(24):7479-84.
Genome PropertyGenProp0687: allantoin catabolism to oxamate and carbamoyl-phosphate (HMM)
GenProp0686: allantoin catabolism to glyoxalate and urea (HMM)