HMM Summary Page: TIGR03173

Functionxanthine permease
Gene SymbolpbuX
Trusted Cutoff414.15
Domain Trusted Cutoff414.15
Noise Cutoff371.25
Domain Noise Cutoff371.25
Isology Typesubfamily
HMM Length407
AuthorSelengut J
Entry DateNov 29 2006 8:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentAll the seed members of this model are observed adjacent to genes for either xanthine phosphoribosyltransferase (for the conversion of xanthine to guanine, GenProp0696, [1]) or genes for the conversion of xanthine to urate and its concomitant catabolism (GenProp0640, GenProp0688, GenProp0686 and GenProp0687). A number of sequences scoring higher than trusted to this model are found in different genomic contexts, and the possibility exist that these transport related compounds in addition to or instead of xanthine itself. The outgroup to this family are sequences which are characterized as uracil permeases or are adjacent to established uracil phosphoribosyltransferases.
ReferencesRN [1] RM PMID: 9098051 RT Xanthine metabolism in Bacillus subtilis: characterization of the xpt-pbuX operon and evidence for purine- and nitrogen-controlled expression of genes involved in xanthine salvage and catabolism. RA Christiansen LC, Schou S, Nygaard P, Saxild HH RL J Bacteriol. 1997 Apr;179(8):2540-50.
Genome PropertyGenProp0696: xanthine utilization as a source of guanine-monophosphate (GMP) (HMM)
GenProp0698: xanthine catabolism to urate (HMM)