HMM Summary Page: TIGR03167

FunctiontRNA 2-selenouridine synthase
Gene SymbolselU
Trusted Cutoff219.75
Domain Trusted Cutoff219.75
Noise Cutoff109.85
Domain Noise Cutoff109.85
Isology Typeequivalog
EC Number2.9.1.-
HMM Length311
Mainrole CategoryProtein synthesis
Subrole CategorytRNA and rRNA base modification
Gene Ontology TermGO:0001887: selenium compound metabolic process biological_process
GO:0006400: tRNA modification biological_process
GO:0016786: selenotransferase activity molecular_function
AuthorHaft DH
Entry DateNov 20 2006 5:03PM
Last ModifiedFeb 14 2011 3:27PM
CommentThe Escherichia coli YbbB protein was shown to encode a selenophosphate-dependent tRNA 2-selenouridine synthase, essential for modification of some tRNAs to replace a sulfur atom with selenium. This enzyme works with SelD, the selenium donor protein, which also acts in selenocysteine incorporation. Although the members of this protein family show a fairly deep split, sequences from both sides of the split are supported by co-occurence with, and often proximity to, the selD gene.
ReferencesRN [1] RM PMID: 14594807 RT Functional diversity of the rhodanese homology domain: the Escherichia coli ybbB gene encodes a selenophosphate-dependent tRNA 2-selenouridine synthase. RA Wolfe MD, Ahmed F, Lacourciere GM, Lauhon CT, Stadtman TC, Larson TJ RL J Biol Chem. 2004 Jan 16;279(3):1801-9. Epub 2003 Oct 31.
Genome PropertyGenProp0692: selenouridine-containing tRNA (HMM)