Accession | TIGR03161 |
Name | ribazole_CobZ |
Function | alpha-ribazole phosphatase CobZ |
Gene Symbol | cobZ |
Trusted Cutoff | 152.50 |
Domain Trusted Cutoff | 152.50 |
Noise Cutoff | 84.00 |
Domain Noise Cutoff | 84.00 |
Isology Type | equivalog |
EC Number | 3.1.3.73 |
HMM Length | 140 |
Mainrole Category | Biosynthesis of cofactors, prosthetic groups, and carriers |
Subrole Category | Heme, porphyrin, and cobalamin |
Gene Ontology Term | GO:0009236: cobalamin biosynthetic process biological_process |
| GO:0019175: alpha-ribazole-5'-P phosphatase activity molecular_function |
Author | Haft DH |
Entry Date | Nov 16 2006 1:38PM |
Last Modified | Feb 14 2011 3:27PM |
Comment | Sequences in the seed alignment were the experimentally characterized CobZ of the methanogenic archaeon Methanosarcina mazei, and other archaeal proteins found similarly next to or very near to other cobalamin biosynthesis genes. CobZ replaces the alpha-ribazole-phosphate phosphatase (EC 3.1.3.73) called CobC in analogous bacterial pathways for cobalamin biosynthesis under anaerobic conditions. |
References | RN [1]
RM PMID: 16547066
RT The cobZ gene of Methanosarcina mazei Go1 encodes the nonorthologous replacement of the alpha-ribazole-5'-phosphate phosphatase (CobC) enzyme of Salmonella enterica.
RA Zayas CL, Woodson JD, Escalante-Semerena JC
RL J Bacteriol. 2006 Apr;188(7):2740-3. |
Genome Property | GenProp0269: coenzyme B12 biosynthesis from cob(II)yrinate diamide (HMM) |