HMM Summary Page: TIGR03160

Functionnicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase
Gene SymbolcobT
Trusted Cutoff319.30
Domain Trusted Cutoff319.30
Noise Cutoff137.65
Domain Noise Cutoff137.65
Isology Typeequivalog
EC Number2.4.2.21
HMM Length334
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryHeme, porphyrin, and cobalamin
Gene Ontology TermGO:0008939: nicotinate-nucleotide-dimethylbenzimidazole phosphoribosyltransferase activity molecular_function
GO:0009236: cobalamin biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 15 2006 4:14PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are nicotinate-nucleotide--dimethylbenzimidazole phosphoribosyltransferase, an enzyme of cobalamin biosynthesis.
ReferencesDR PFAM; PF02277; DBI_PRT; Phosphoribosyltransferase RN [1] RM PMID: 11441022 RT Structural investigation of the biosynthesis of alternative lower ligands for cobamides by nicotinate mononucleotide: 5,6-dimethylbenzimidazole phosphoribosyltransferase from Salmonella enterica. RA Cheong CG, Escalante-Semerena JC, Rayment I RL J Biol Chem. 2001 Oct 5;276(40):37612-20. Epub 2001 Jul 5.
Genome PropertyGenProp0269: coenzyme B12 biosynthesis from cob(II)yrinate diamide (HMM)