HMM Summary Page: TIGR03156

FunctionGTP-binding protein HflX
Gene SymbolhflX
Trusted Cutoff216.75
Domain Trusted Cutoff216.75
Noise Cutoff123.05
Domain Noise Cutoff123.05
Isology Typeequivalog
HMM Length351
Mainrole CategoryUnknown function
Subrole CategoryGeneral
Gene Ontology TermGO:0005525: GTP binding molecular_function
GO:0008150: biological_process biological_process
AuthorHaft DH
Entry DateNov 14 2006 9:54AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family is one of a number of homologous small, well-conserved GTP-binding proteins with pleiotropic effects. Bacterial members are designated HflX, following the naming convention in Escherichia coli where HflX is encoded immediately downstream of the RNA chaperone Hfq, and immediately upstream of HflKC, a membrane-associated protease pair with an important housekeeping function. Over large numbers of other bacterial genomes, the pairing with hfq is more significant than with hflK and hlfC. The gene from Homo sapiens in this family has been named PGPL (pseudoautosomal GTP-binding protein-like).
ReferencesRN [1] RM PMID: 8248183 RT The Escherichia coli hflA locus encodes a putative GTP-binding protein and two membrane proteins, one of which contains a protease-like domain. RA Noble JA, Innis MA, Koonin EV, Rudd KE, Banuett F, Herskowitz I RL Proc Natl Acad Sci U S A. 1993 Nov 15;90(22):10866-70. RN [2] RM PMID: 9466997 RT A novel pseudoautosomal gene encoding a putative GTP-binding protein resides in the vicinity of the Xp/Yp telomere. RA Gianfrancesco F, Esposito T, Montanini L, Ciccodicola A, Mumm S, Mazzarella R, Rao E, Giglio S, Rappold G, Forabosco A RL Hum Mol Genet. 1998 Mar;7(3):407-14.