HMM Summary Page: TIGR03140

Functionalkyl hydroperoxide reductase subunit F
Gene SymbolahpF
Trusted Cutoff502.90
Domain Trusted Cutoff502.90
Noise Cutoff400.10
Domain Noise Cutoff400.10
Isology Typeequivalog
EC Number1.8.1.-
HMM Length515
Mainrole CategoryCellular processes
Subrole CategoryDetoxification
Gene Ontology TermGO:0006805: xenobiotic metabolic process biological_process
GO:0009398: FMN biosynthetic process biological_process
GO:0016668: oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor molecular_function
AuthorSelengut J
Entry DateNov 2 2006 4:45PM
Last ModifiedJun 19 2012 9:42AM
CommentThis enzyme is the partner of the peroxiredoxin (alkyl hydroperoxide reductase) AhpC which contains the peroxide-reactive cysteine. AhpF contains the reductant (NAD(P)H) binding domain (PF00070) and presumably acts to resolve the disulfide which forms after oxidation of the active site cysteine in AphC [1]. This proteins contains two paired conserved cysteine motifs, CxxCP and CxHCDGP.
ReferencesRN [1] RM PMID: 10482511 RT Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis. RA Rocha ER, Smith CJ RL J Bacteriol. 1999 Sep;181(18):5701-10.
Genome PropertyGenProp0676: alkylhydroperoxide reductase AhpCF (peroxiredoxin) (HMM)