Accession | TIGR03140 |
Name | AhpF |
Function | alkyl hydroperoxide reductase subunit F |
Gene Symbol | ahpF |
Trusted Cutoff | 502.90 |
Domain Trusted Cutoff | 502.90 |
Noise Cutoff | 400.10 |
Domain Noise Cutoff | 400.10 |
Isology Type | equivalog |
EC Number | 1.8.1.- |
HMM Length | 515 |
Mainrole Category | Cellular processes |
Subrole Category | Detoxification |
Gene Ontology Term | GO:0006805: xenobiotic metabolic process biological_process |
| GO:0009398: FMN biosynthetic process biological_process |
| GO:0016668: oxidoreductase activity, acting on a sulfur group of donors, NAD or NADP as acceptor molecular_function |
Author | Selengut J |
Entry Date | Nov 2 2006 4:45PM |
Last Modified | Jun 19 2012 9:42AM |
Comment | This enzyme is the partner of the peroxiredoxin (alkyl hydroperoxide reductase) AhpC which contains the peroxide-reactive cysteine. AhpF contains the reductant (NAD(P)H) binding domain (PF00070) and presumably acts to resolve the disulfide which forms after oxidation of the active site cysteine in AphC [1]. This proteins contains two paired conserved cysteine motifs, CxxCP and CxHCDGP. |
References | RN [1]
RM PMID: 10482511
RT Role of the alkyl hydroperoxide reductase (ahpCF) gene in oxidative stress defense of the obligate Anaerobe bacteroides fragilis.
RA Rocha ER, Smith CJ
RL J Bacteriol. 1999 Sep;181(18):5701-10. |
Genome Property | GenProp0676: alkylhydroperoxide reductase AhpCF (peroxiredoxin) (HMM) |