HMM Summary Page: TIGR03139

Function7-cyano-7-deazaguanine reductase
Gene SymbolqueF
Trusted Cutoff86.90
Domain Trusted Cutoff86.90
Noise Cutoff81.05
Domain Noise Cutoff81.05
Isology Typeequivalog
EC Number1.7.1.13
HMM Length115
AuthorSelengut J
Entry DateNov 2 2006 3:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis enzyme catalyzes the 4-electron reduction of the cyano group of 7-cyano-7-deazaguanine (proQ1) to an amine [1]. Although related to a large family of GTP cyclohydrolases (PF01227), the relationship is structural and not germane to the catalytic mechanism. This mode represents the shorter, gram-positive version of the enzyme as found in B. subtilis. The enzymatic step represents the first point at which the biosynthesis of queuosine in bacteria and eukaryotes is distinguished from the biosynthesis of archaeosine in archaea.
ReferencesRN [1] RM PMID: 15767583 RT From cyclohydrolase to oxidoreductase: discovery of nitrile reductase activity in a common fold. RA Van Lanen SG, Reader JS, Swairjo MA, de Crecy-Lagard V, Lee B, Iwata-Reuyl D RL Proc Natl Acad Sci U S A. 2005 Mar 22;102(12):4264-9. Epub 2005 Mar 14. DR HAMAP; MF_00818; 152 of 153
Genome PropertyGenProp0677: queuosine (Q-tRNA) biosynthesis from preQ0 (HMM)