HMM Summary Page: TIGR03135

Functionmalonate decarboxylase holo-[acyl-carrier-protein] synthase
Gene SymbolmdcG
Trusted Cutoff99.70
Domain Trusted Cutoff99.70
Noise Cutoff81.40
Domain Noise Cutoff81.40
Isology Typeequivalog
EC Number2.7.7.66
HMM Length205
Mainrole CategoryEnergy metabolism
Subrole CategoryOther
Gene Ontology TermGO:0050519: holo-citrate lyase synthase activity molecular_function
GO:0051191: prosthetic group biosynthetic process biological_process
AuthorHaft DH
Entry DateNov 1 2006 11:27AM
Last ModifiedFeb 14 2011 3:27PM
CommentMalonate decarboxylase, like citrate lyase, has a unique acyl carrier protein subunit with a prosthetic group derived from, and distinct from, coenzyme A. Members of this protein family are the phosphoribosyl-dephospho-CoA transferase specific to the malonate decarboxylase system. This enzyme can also be designated holo-ACP synthase ( The corresponding component of the citrate lyase system, CitX, shows little or no sequence similarity to this family.
ReferencesRN [1] RM PMID: 11052675 RT Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. RA Hoenke S, Wild MR, Dimroth P RL Biochemistry. 2000 Oct 31;39(43):13223-32.
Genome PropertyGenProp0674: malonate decarboxylase (HMM)