HMM Summary Page: TIGR03132

Functiontriphosphoribosyl-dephospho-CoA synthase MdcB
Gene SymbolmdcB
Trusted Cutoff282.35
Domain Trusted Cutoff282.35
Noise Cutoff279.65
Domain Noise Cutoff279.65
Isology Typeequivalog
EC Number2.4.2.52
HMM Length272
Mainrole CategoryBiosynthesis of cofactors, prosthetic groups, and carriers
Subrole CategoryOther
Gene Ontology TermGO:0019361: 2'-(5''-triphosphoribosyl)-3'-dephospho-CoA biosynthetic process biological_process
GO:0046917: triphosphoribosyl-dephospho-CoA synthase activity molecular_function
AuthorHaft DH
Entry DateOct 31 2006 3:06PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein acts in cofactor biosynthesis, preparing the coenzyme A derivative that becomes attached to the malonate decarboxylase acyl carrier protein (or delta subunit). The closely related protein CitG of citrate lyase produces the same molecule, but the two families are nonetheless readily separated.
ReferencesRN [1] RM PMID: 11052675 RT Biosynthesis of triphosphoribosyl-dephospho-coenzyme A, the precursor of the prosthetic group of malonate decarboxylase. RA Hoenke S, Wild MR, Dimroth P RL Biochemistry. 2000 Oct 31;39(43):13223-32.
Genome PropertyGenProp0674: malonate decarboxylase (HMM)