HMM Summary Page: TIGR03127

Function6-phospho 3-hexuloisomerase
Gene SymbolhxlB
Trusted Cutoff192.05
Domain Trusted Cutoff192.05
Noise Cutoff101.95
Domain Noise Cutoff101.95
Isology Typeequivalog_domain
EC Number5.3.-.-
HMM Length179
AuthorHaft DH
Entry DateOct 30 2006 12:41PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are 6-phospho 3-hexuloisomerase (PHI), or the PHI domain of a fusion protein. This enzyme is part of the ribulose monophosphate (RuMP) pathway, which in one direction removes the toxic metabolite formaldehyde by assimilation into fructose-6-phosphate. In the other direction, in species lacking a complete pentose phosphate pathway, the RuMP pathway yields ribulose-5-phosphate, necessary for nucleotide biosynthesis, at the cost of also yielding formaldehyde. These latter species tend usually have a formaldehyde-activating enzyme to attach formaldehyde to the C1 carrier tetrahydromethanopterin.
Genome PropertyGenProp0673: ribulose monophosphate pathway (HMM)