HMM Summary Page: TIGR03126

Functionformaldehyde-activating enzyme
Gene Symbolfae
Trusted Cutoff118.05
Domain Trusted Cutoff118.05
Noise Cutoff31.15
Domain Noise Cutoff31.15
Isology Typeequivalog_domain
HMM Length160
AuthorHaft DH
Entry DateOct 30 2006 10:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis family consists of formaldehyde-activating enzyme, or the corresponding domain of longer, bifunctional proteins. It links formaldehyde to the C1 carrier tetrahydromethanopterin (H4MPT), an analog of tetrahydrofolate, and is common among species with H4MPT. The ribulose monophosphate (RuMP) pathway, which removes the toxic metabolite formaldehyde by assimilation, runs in the opposite direction in some species to produce ribulose 5-phosphate for nucleotide biosynthesis, leaving formaldehyde as an additional metabolite. In these species, formaldehyde activating enzyme may occur as a fusion protein with D-arabino 3-hexulose 6-phosphate formaldehyde lyase from the RuMP pathway.
ReferencesDR SP; Q9FA38; Methylobacterium extorquens AM1 DR HAMAP; MF_01268; 12 of 12
Genome PropertyGenProp0671: H4MPT-linked C1 transfer pathway (HMM)