HMM Summary Page: TIGR03123

Functionprobable H4MPT-linked C1 transfer pathway protein
Trusted Cutoff244.10
Domain Trusted Cutoff244.10
Noise Cutoff113.00
Domain Noise Cutoff113.00
Isology Typehypoth_equivalog
HMM Length327
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOne-carbon metabolism
AuthorHaft DH
Entry DateOct 28 2006 10:13PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family was identified, by the method of partial phylogenetic profiling, as related to the use of tetrahydromethanopterin (H4MPT) as a C-1 carrier. Characteristic markers of the H4MPT-linked C1 transfer pathway include formylmethanofuran dehydrogenase subunits, methenyltetrahydromethanopterin cyclohydrolase, etc. Tetrahydromethanopterin, a tetrahydrofolate analog, occurs in methanogenic archaea, bacterial methanotrophs, planctomycetes, and a few other lineages.