HMM Summary Page: TIGR03121

Functionformylmethanofuran dehydrogenase subunit A
Trusted Cutoff392.75
Domain Trusted Cutoff392.75
Noise Cutoff69.30
Domain Noise Cutoff69.30
Isology Typeequivalog
EC Number1.2.99.5
HMM Length556
AuthorHaft DH
Entry DateOct 26 2006 4:57PM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this largely archaeal protein family are subunit A of the formylmethanofuran dehydrogenase. Nomenclature in some bacteria may reflect inclusion of the formyltransferase described by TIGR03119 as part of the complex, and therefore call this protein formyltransferase/hydrolase complex Fhc subunit A. Note that this model does not distinguish tungsten (FwdA) from molybdenum-containing (FmdA) forms of this enzyme; a single gene from this family is expressed constitutively in Methanobacterium thermoautotrophicum, which has both tungsten and molybdenum forms and may work interchangeably.
ReferencesRN [1] RM PMID: 8954165 RT The molybdenum formylmethanofuran dehydrogenase operon and the tungsten formylmethanofuran dehydrogenase operon from Methanobacterium thermoautotrophicum. Structures and transcriptional regulation. RA Hochheimer A, Linder D, Thauer RK, Hedderich R RL Eur J Biochem. 1996 Nov 15;242(1):156-62.
Genome PropertyGenProp0671: H4MPT-linked C1 transfer pathway (HMM)