HMM Summary Page: TIGR03119

Functionformylmethanofuran--tetrahydromethanopterin N-formyltransferase
Gene SymbolfhcD
Trusted Cutoff292.60
Domain Trusted Cutoff292.60
Noise Cutoff94.05
Domain Noise Cutoff94.05
Isology Typeequivalog
EC Number2.3.1.101
HMM Length288
Mainrole CategoryCentral intermediary metabolism
Subrole CategoryOne-carbon metabolism
AuthorHaft DH
Entry DateOct 26 2006 10:48AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the FhcD protein of tetrahydromethanopterin (H4MPT)-dependent C-1 carrier metabolism. In the archaea, FhcD is designated formylmethanofuran--tetrahydromethanopterin N-formyltransferase, while in bacteria it is commonly designated as formyltransferase/hydrolase complex subunit D. FhcD is essential for one-carbon metabolism in at least three groups of prokaryotes: methanogenic archaea, sulfate-reducing archaea, and methylotrophic bacteria.
ReferencesDR PFAM; PF01913; Formylmethanofuran--tetrahydromethanopterin formyltransferase, distal lobe RN [1] RM PMID: 16466742 RT The structure of formylmethanofuran: tetrahydromethanopterin formyltransferase in complex with its coenzymes. RA Acharya P, Warkentin E, Ermler U, Thauer RK, Shima S RL J Mol Biol. 2006 Mar 31;357(3):870-9. Epub 2006 Jan 23. RN [2] RM PMID: 16011764 RT Development and application of polymerase chain reaction primers based on fhcD for environmental detection of methanopterin-linked C1-metabolism in bacteria. RA Kalyuzhnaya MG, Nercessian O, Lidstrom ME, Chistoserdova L RL Environ Microbiol. 2005 Aug;7(8):1269-74. DR HAMAP; MF_00579; 13 of 13
Genome PropertyGenProp0671: H4MPT-linked C1 transfer pathway (HMM)