HMM Summary Page: TIGR03110

Functionexosortase family protein XrtG
Gene SymbolxrtG
Trusted Cutoff102.75
Domain Trusted Cutoff102.75
Noise Cutoff67.95
Domain Noise Cutoff67.95
Isology Typehypoth_equivalog
HMM Length187
AuthorHaft DH
Entry DateOct 16 2006 5:20PM
Last ModifiedFeb 10 2012 12:35PM
CommentMembers of this protein family are found in a modest number of non-pathogenic Gram-positive bacteria, including three species of Lactococcus and three paralogs in Clostridium acetobutylicum. This protein appears related to the conserved core region of a family of proposed transpeptidases, exosortase (previously EpsH), thought to act on PEP-CTERM proteins. Members of the seed alignment include all exosortase proposed active site residues. However, in contrast to canonical exosortase (TIGR02602) and archaeal (TIGR03762), and cyanobacterial (TIGR03763) variants, this family has not yet been matched to a cognate PEP-CTERM-like sorting signal. This protein is assigned the gene symbol XrtG (eXosoRTase family protein of Gram-positives).
ReferencesRN [1] RM PMID:22037399 RT Archaeosortases and exosortases are widely distributed systems linking membrane transit with posttranslational modification. RA Haft DH, Payne SH, Selengut JD RL J Bacteriol. 2012 Jan;194(1):36-48. Epub 2011 Oct 28.
Genome PropertyGenProp0669: protein sorting system, putative, exosortase G class (HMM)