HMM Summary Page: TIGR03098

Functionacyl-CoA ligase (AMP-forming), exosortase A-associated
Trusted Cutoff592.35
Domain Trusted Cutoff592.35
Noise Cutoff525.25
Domain Noise Cutoff525.25
Isology Typehypoth_equivalog
HMM Length517
AuthorSelengut J
Entry DateOct 11 2006 11:20AM
Last ModifiedJun 8 2011 1:44PM
CommentThis group of proteins contains an AMP-binding domain (PF00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system [1], specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present.
ReferencesRN [1] RM PMID: 16930487 RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic. RA Haft DH, Paulsen IT, Ward N, Selengut JD RL BMC Biol. 2006 Aug 24;4(1):29.
Genome PropertyGenProp0652: exopolysaccharide biosynthesis, exosortase A-associated (HMM)