| Accession | TIGR03098 |
| Name | ligase_PEP_1 |
| Function | acyl-CoA ligase (AMP-forming), exosortase A-associated |
| Trusted Cutoff | 592.35 |
| Domain Trusted Cutoff | 592.35 |
| Noise Cutoff | 525.25 |
| Domain Noise Cutoff | 525.25 |
| Isology Type | hypoth_equivalog |
| HMM Length | 517 |
| Author | Selengut J |
| Entry Date | Oct 11 2006 11:20AM |
| Last Modified | Jun 8 2011 1:44PM |
| Comment | This group of proteins contains an AMP-binding domain (PF00501) associated with acyl CoA-ligases. These proteins are generally found in genomes containing the exosortase/PEP-CTERM protein expoert system [1], specifically the type 1 variant of this system described by the Genome Property GenProp0652. When found in this context they are invariably present next to a decarboxylase enzyme. A number of sequences from Burkholderia species also hit this model, but the genomic context is obviously different. The hypothesis of a constant substrate for this family is only strong where the exosortase context is present. |
| References | RN [1]
RM PMID: 16930487
RT Exopolysaccharide-associated protein sorting in environmental organisms: the PEP-CTERM/EpsH system. Application of a novel phylogenetic profiling heuristic.
RA Haft DH, Paulsen IT, Ward N, Selengut JD
RL BMC Biol. 2006 Aug 24;4(1):29. |
| Genome Property | GenProp0652: exopolysaccharide biosynthesis, exosortase A-associated (HMM) |
