HMM Summary Page: TIGR03090

Functionsmall, acid-soluble spore protein tlp
Gene Symboltlp
Trusted Cutoff72.90
Domain Trusted Cutoff72.90
Noise Cutoff35.95
Domain Noise Cutoff35.95
Isology Typeequivalog
HMM Length70
Mainrole CategoryCellular processes
Subrole CategorySporulation and germination
AuthorHaft DH
Entry DateOct 6 2006 1:24PM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family is restricted to a subset of endospore-forming bacteria such as Bacillus subtilis, all of which are in the Firmicutes (low-GC Gram-positive) lineage. Although previously designated tlp (thioredoxin-like protein), the B. subtilis protein was shown to be a minor small acid-soluble spore protein SASP, unique to spores. The motif E[VIL]XDE near the C-terminus probably represents at a germination protease cleavage site.
ReferencesRN [1] RM PMID: 9852018 RT New small, acid-soluble proteins unique to spores of Bacillus subtilis: identification of the coding genes and regulation and function of two of these genes. RA Bagyan I, Setlow B, Setlow P RL J Bacteriol. 1998 Dec;180(24):6704-12.