HMM Summary Page: TIGR03083

Functionuncharacterized Actinobacterial protein TIGR03083
Trusted Cutoff50.00
Domain Trusted Cutoff50.00
Noise Cutoff41.55
Domain Noise Cutoff41.55
Isology Typedomain
HMM Length202
AuthorHaft DH
Entry DateOct 3 2006 9:42AM
Last ModifiedFeb 14 2011 3:27PM
CommentThis protein family pulls together several groups of proteins, each very different from the others. They share in common three conserved regions. The first is a region of about 38 amino acids, nearly always at the N-terminus of a protein. This region has a bulky hydrophobic residue, usually Trp, at position 29, and a His residue at position 37 that is invariant, so far, in over 150 instances. The second conserved region has a motif [DE]xxxHxxD. The third conserved region contains a hydrophobic patch and a well-conserved Arg residue. Most examples are found in the Actinobacteria, including the genera Mycobacterium, Corynebacterium, Streptomyces, Nocardia, Frankia, etc. The pattern of near-invariant residues against a backdrop of extreme sequence divergence suggests enzymatic activity and conservation of active site residues.