HMM Summary Page: TIGR03081

Functionmethylmalonyl-CoA epimerase
Gene Symbolmce
Trusted Cutoff114.95
Domain Trusted Cutoff114.95
Noise Cutoff60.30
Domain Noise Cutoff60.30
Isology Typeequivalog
EC Number5.1.99.1
HMM Length129
AuthorHaft DH
Entry DateSep 28 2006 8:13AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are the enzyme methylmalonyl-CoA epimerase (EC, also called methylmalonyl-CoA racemase. This enzyme converts (2R)-methylmalonyl-CoA to (2S)-methylmalonyl-CoA, which is then a substrate for methylmalonyl-CoA mutase (TIGR00642). It is known in bacteria, archaea, and as a mitochondrial protein in animals. It is closely related to lactoylglutathione lyase (TIGR00068), which is also called glyoxylase I, and is also a homodimer.
ReferencesRN [1] RM PMID: 11481338 RT Identification of the human methylmalonyl-CoA racemase gene based on the analysis of prokaryotic gene arrangements. Implications for decoding the human genome. RA Bobik TA, Rasche ME RL J Biol Chem. 2001 Oct 5;276(40):37194-8. RN [2] RM PMID: 11470438 RT Crystal structure of methylmalonyl-coenzyme A epimerase from P. shermanii: a novel enzymatic function on an ancient metal binding scaffold. RA McCarthy AA, Baker HM, Shewry SC, Patchett ML, Baker EN RL Structure. 2001 Jul 3;9(7):637-46. DR BRENDA;; Methylmalonyl-CoA epimerase DR PFAM; PF00903; glyoxalase family protein
Genome PropertyGenProp0755: pyruvate conversion to propionate, anaerobic, FAD/NAD-regenerating (HMM)