HMM Summary Page: TIGR03075

FunctionPQQ-dependent dehydrogenase, methanol/ethanol family
Trusted Cutoff480.05
Domain Trusted Cutoff480.05
Noise Cutoff249.80
Domain Noise Cutoff249.80
Isology Typesubfamily
EC Number1.1.2.-
HMM Length530
Gene Ontology TermGO:0016491: oxidoreductase activity molecular_function
GO:0050662: coenzyme binding molecular_function
AuthorHaft DH
Entry DateSep 20 2006 1:12PM
Last ModifiedMar 6 2014 3:28PM
CommentThis protein family has a phylogenetic distribution very similar to that coenzyme PQQ biosynthesis enzymes, as shown by partial phylogenetic profiling. Genes in this family often are found adjacent to the PQQ biosynthesis genes themselves. An unusual, strained disulfide bond between adjacent Cys residues contributes to PQQ-binding, as does a Trp residue that is part of a PQQ enzyme repeat (see PF01011). Characterized members include the dehydrogenase subunit of a membrane-anchored, three subunit alcohol (ethanol) dehydrogenase of Gluconobacter suboxydans, a homodimeric ethanol dehydrogenase in Pseudomonas aeruginosa, and the large subunit of an alpha2/beta2 heterotetrameric methanol dehydrogenase in Methylobacterium extorquens.
ReferencesDR PFAM; PF01011; PQQ enzyme repeat RN [1] RM PMID:19224199 RT Quinoprotein ethanol dehydrogenase from Pseudomonas aeruginosa: the unusual disulfide ring formed by adjacent cysteine residues is essential for efficient electron transfer to cytochrome c550. RA Mennenga B, Kay CW, Gorisch H RL Arch Microbiol. 2009 Apr;191(4):361-7. doi: 10.1007/s00203-009-0460-4.
Genome PropertyGenProp0170: coenzyme PQQ biosynthesis (HMM)
GenProp1101: quinoprotein cytochrome relay system (HMM)