HMM Summary Page: TIGR03073

Functionrelease factor H-coupled RctB family protein
Trusted Cutoff271.80
Domain Trusted Cutoff271.80
Noise Cutoff234.70
Domain Noise Cutoff234.70
Isology Typehypoth_equivalog
HMM Length356
Mainrole CategoryProtein synthesis
Subrole CategoryOther
Gene Ontology TermGO:0003674: molecular_function molecular_function
GO:0006415: translational termination biological_process
AuthorHaft DH
Entry DateSep 18 2006 11:29AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this family are related to RctB. RctB a protein of known structure but unknown function that often is encoded near RNA cyclase and therefore is suggested to be a tRNA or mRNA processing enzyme. This family of RctB-like proteins in encoded upstream of, and apparently is translationally coupled to, the putative peptide chain release factor RF-H (TIGR03072), product of the prfH gene. Note that a large deletion at the junction between this gene and the prfH gene in Escherichia coli K-12 marks both as probable pseudogenes.
ReferencesRN [1] RM PMID: 16970810 RT Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons. RA Baranov PV, Vestergaard B, Hamelryck T, Gesteland RF, Nyborg J, Atkins JF RL Biol Direct. 2006 Sep 13;1(1):28.
Genome PropertyGenProp0665: peptide chain release operon, RctB-like/PrfH (HMM)