HMM Summary Page: TIGR03072

Functionputative peptide chain release factor H
Gene SymbolprfH
Trusted Cutoff166.65
Domain Trusted Cutoff166.65
Noise Cutoff142.70
Domain Noise Cutoff142.70
Isology Typeequivalog
HMM Length200
Mainrole CategoryProtein synthesis
Subrole CategoryTranslation factors
Gene Ontology TermGO:0003747: translation release factor activity molecular_function
GO:0006415: translational termination biological_process
AuthorHaft DH
Entry DateSep 18 2006 10:45AM
Last ModifiedFeb 14 2011 3:27PM
CommentMembers of this protein family are bacterial proteins homologous to peptide chain release factors 1 (RF-1, product of the prfA gene), and 2 (RF-2, product of the prfB gene). The member from Escherichia coli K-12, designated prfH, appears to be a pseudogene. This class I release factor is always found as the downstream gene of a two-gene operon.
ReferencesRN [1] RM PMID: 16970810 RT Diverse bacterial genomes encode an operon of two genes, one of which is an unusual class-I release factor that potentially recognizes atypical mRNA signals other than normal stop codons. RA Baranov PV, Vestergaard B, Hamelryck T, Gesteland RF, Nyborg J, Atkins JF RL Biol Direct. 2006 Sep 13;1(1):28.
Genome PropertyGenProp0665: peptide chain release operon, RctB-like/PrfH (HMM)