HMM Summary Page: TIGR03063

Functionsortase B cell surface sorting signal
Trusted Cutoff18.15
Domain Trusted Cutoff18.15
Noise Cutoff17.60
Domain Noise Cutoff17.60
Isology Typedomain
HMM Length29
AuthorHaft DH
Entry DateSep 6 2006 11:12AM
Last ModifiedFeb 14 2011 3:27PM
CommentTwo different classes of sorting signal, both analogous to the sortase A signal LPXTG, may be recognized by the sortase SrtB. These are given as NXZTN and NPKXZ. Proteins sorted by this class of sortase are less common than the sortase A and LPXTG system. This model describes a number of cell surface protein C-terminal regions from Gram-positive bacteria that appear to be sortase B (SrtB) sorting signals.
ReferencesRN [1] RM PMID: 16247833 RT Identification of substrates of the Listeria monocytogenes sortases A and B by a non-gel proteomic analysis. RA Pucciarelli MG, Calvo E, Sabet C, Bierne H, Cossart P, Garcia-del Portillo F RL Proteomics. 2005 Dec;5(18):4808-17.
Genome PropertyGenProp0664: protein sorting system, sortase type, SrtB class (HMM)